antihistaminic and anticholinergic activity of methanolic extract of barberry fruit (berberis vulgaris) in the guinea- pig ileum

Authors

r khosrokhavar food and drug laboratory research center (fdlrc), moh & me, tehran, iran tel: +98 - 21 - 66463613, fax: +98-21 - 66404330

a ahmadiani department of pharmacology, faculty of medicine, the medical sciences university of shaheed beheshti

f shamsa department of chemistry, faculty of pharmacy, the medical sciences university of tehran

abstract

background: barberry (berberris vulgaris) is a well known medicinal plant in iran and has also been used as food. objective: this study was conducted to evaluate antihistaminic and anticholinergic activity of methanolic extract of barberry fruit. methods: methanolic extract was prepared and pharmacologically studied on isolated guinea- pig ileum, dose- response curves of histamine and acetylcholine with and without methanolic extract were plotted. results: the pa2 values for antihistaminic activity of methanolic extract and dexchlorpheniramine were calculated (extract pa2± s.e.m = 3.53 ± 0.16 [-logc(g/l)] dexchlorpheniramine pa2 ± s.e.m.= 9.36 ± 0.14 ([-logc (m)]) and compared with each other. the pa2 values of anticholinergic activity of methanolic extract and atropine were also calculated (extract pa2± s.e.m = 4.18 ± 0.17 [-logc(g/)] atropine, pa2 +s.e.m = 8.99 ± 0.13 [-logc(m)]) and compared. conclusion: the results indicated antihistaminic and anticholinergic activity of methanolic extract.

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Journal title:
فصلنامه علمی پژوهشی گیاهان دارویی

جلد ۳، شماره ۳۵، صفحات ۹۹-۱۰۵

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